Pair-beam propagation in a magnetised plasma for modelling the polarized radiation emission from gamma-ray bursts in laboratory astrophysics experiments

The propagation of a relativistic electron-positron beam in a magnetized electron-ion plasma is studied, focusing on the polarization of the radiation generated in this case. Special emphasis is laid on investigating the polarization of the generated radiation for a range of beam-plasma parameters, transverse and longitudinal beam sizes, and the external magnetic fields. Our results not only help in understanding the high degrees of circular polarization observed in gamma-rays bursts but they also help in distinguishing the different modes associated with the filamentation dynamics of the pair-beam in laboratory astrophysics experiments

A design and optimization assistant for induction motors and generators

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1998.Includes bibliographical references (p. [173]-181).by Ujjwal Sinha.Ph.D

Design and Implementation of a (2, 2) and a (2, 3) Visual Cryptographic Scheme

In this paper two methods for (2, 2) and (2, 3) visual cryptographic scheme(VCS) is proposed. The first scheme considers 4 pixels of input image at a time and generates 4 output pixels in each share. As 4 output pixels are generated from 4 input pixels dimension and aspect ratio of the decrypted image remain same during the process. The second scheme considers 2 pixels (1 block) of input image at a time and generates 3 output pixels in each share. Here probability of 1/3 for black pixel is maintained in each share. The scheme improves the contrast of output image. The dimension of revealed image is increased by 1.5 times in horizontal direction and remains same in vertical direction

Adverse drug reactions due to gabapentin-nortriptyline in patients with neuropathic pain in a tertiary care teaching hospital

Gabapentin and Nortriptyline are used to treat neuropathic pain. Gabapentin belongs to a group of drugs called anti-convulsant and Nortriptyline belongs to tricyclic antidepressant. Gabapentin acts by binding to the specific site on voltage- gated calcium channels. This helps in relieving nerve pain and lowers the risk of seizure. Nortriptyline works by preventing the released chemical messengers in brain (serotonin and norepinephrine) from being reabsorbed back into the nerve cells. As a result, it prolongs the effect of serotonin and norepinephrine in the brain and over time, this helps to relieve depression and lighten the mood. We are reporting a case series including 3 patients having neuropathic pain and taking tablet gabapentin-nortriptyline in department of neurology, Patna medical college and hospital, Patna developed some adverse drug reactions. Causality assessment was done in each case by Naranjo scale. Each case was filled properly in ADR (adverse drug reaction) reporting form and was sent to nearby adverse drug reaction monitoring centre (AMC). During the posting for pharmacovigilance in neurology department of Patna medical college and hospital, Patna from 01/07/2022 to 30/09/2022 we got three adverse drug reactions due to gabapentin-nortriptyline. Two of them were due to Gabapentin and one was due to nortriptyline. Gabapentin-nortriptyline is one of the most commonly used drugs in neurology department. It causes some frequent as well as some rare adverse drug reactions which are required to be assessed and finally reported to the nearby AMC

Synthesis of Phosphorodiamidate Morpholino Oligonucleotides Using Trityl and Fmoc Chemistry-A New Method Amenable to Automated Synthesizer

Phosphorodiamidatemorpholino oligonucleotides (PMO) are routinely used for gene silencing and the recently developed PMO-based drug “Exondys51” has highlighted the importance of PMO as excellent antisense reagents. However, the synthesis of PMO has remained challenging. Here a method for the synthesis of PMO using either trityl or Fmoc-protected active morpholino monomers using chlorophosphoramidate chemistry in the presence of a suitable coupling agent on a solid support has been reported. After screening several coupling agents (tetrazole, 1,2,4-triazole, ETT, iodine, LiBr and dicyanoimidazole), ETT and iodine were found to be suitable for efficient coupling. Fmoc chemistry was not known for PMO synthesis because the preparation of Fmoc-protected chlorophosphoramidate monomers was not trivial. Synthesis of Fmoc-protected activated monomers and their use in PMO synthesis is reported for the first time. 25-mer PMO has been synthesized using both the methods and validated in vivo in the zebrafish model by targeting the no tail gene. Methods have been transferred in DNA synthesizer which has become user friendly for PMO synthesis and opened a new avenue to explore PMO for various applications. Fmoc chemistry could be suitable for scalable approach of PMO synthesis using peptide synthesizer as it is a neutral oligomer like peptide.</p

HORIZON 2020 EuPRAXIA Design Study

The Horizon 2020 Project EuPRAXIA (European Plasma Research Accelerator with eXcellence In Applications) aims at producing a design report of a highly compact and cost-effective European facility with multi-GeV electron beams using plasma as the acceleration medium. The accelerator facility will be based on a laser and/or a beam driven plasma acceleration approach and will be used for photon science, high-energy physics (HEP) detector tests, and other applications such as compact X-ray sources for medical imaging or material processing. EuPRAXIA started in November 2015 and will deliver the design report in October 2019. EuPRAXIA aims to be included on the ESFRI roadmap in 2020